\n\u2192 Invitation <\/strong>to give a plenary lecture at the 3e Franco-Japonese DevBio meeting, from 7th to 10th Nov 2022, in Strasbourg
\n<\/strong><\/h5>\n
\u2192 Prize of 1000 \u20ac<\/strong><\/h5>\nThe 2022 SFBD Thesis Prize has been awarded to Dr. H\u00e9l\u00e8ne VIGNES for her thesis entitled \u201cMolecular and cellular processes involved in the morphogenesis of the zebrafish atrio-ventricular canal\u201d. H\u00e9l\u00e8ne did her thesis under the supervision of Dr. Julien Vermot, at the “Institut de G\u00e9n\u00e9tique et Biologie Moleculaire et Cellulaire<\/a>\u201d in Strasbourg. The most important part of her doctoral work has been published in the journal \u2018Developmental Cell<\/a>\u2019.<\/p>\n![\"\"](\"https:\/\/sfbd.fr\/wp-content\/uploads\/2022\/11\/photo-re\u0301cente-300x300.jpg\")
The work of the winner:<\/h5>\n
H\u00e9l\u00e8ne Vignes exploited a remarkably interdisciplinary combination of genetics, modelling, imaging and cell biology techniques to study the formation of the atrio-ventricular canal (AVC), a region of the developing heart that gives rise to the cardiac valves. During development this structure is characterized by a higher cellular density than the surrounding regions of the developing heart. H\u00e9l\u00e8ne first showed that this is due to a significant cell volume decrease at the AVC region, then demonstrated that such a decrease in size is controlled by the mechanical forces generated by the cell microenvironment such as blood flow, heart contraction, ExtraCellular Matrix (ECM) composition. She even went on to identify several of the molecular players involved in this process and could show that Hyaluronic Acid, an ECM component, and two stretch-sensitive transmembrane channels, TRPP2 and TRPV4, are required to induce cell volume decrease.![\"\"](\"https:\/\/sfbd.fr\/wp-content\/uploads\/2022\/11\/Figure-re\u0301sume\u0301.jpg\")
<\/p>\n
The jury considered that H\u00e9l\u00e8ne\u2019s work and the resulting publication are absolutely remarkable in that they underlie how multiple genetic, biochemical and mechanical cues orchestrate together the complex choreography of animal organogenesis. Besides, H\u00e9l\u00e8ne\u2019s thesis manuscript was considered exemplary for its exhaustivity, concision, clarity and accessibility.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_btn title=”Thesis Link” color=”black” link=”url:https%3A%2F%2Fwww.theses.fr%2Fs269491%23|target:_blank”][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] First prize : \u2192 Invitation to give a plenary lecture at the 3e Franco-Japonese DevBio meeting, from 7th to…<\/p>\n","protected":false},"author":6,"featured_media":10370,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"yoast_head":"\n
Thesis Prize SFBD 2022: Dr. H\u00e9l\u00e8ne Vignes - SFBD<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sfbd.fr\/en\/2022\/11\/15\/prix-de-these-sfbd-2022-dr-helene-vignes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thesis Prize SFBD 2022: Dr. H\u00e9l\u00e8ne Vignes - SFBD\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text] First prize : \u2192 Invitation to give a plenary lecture at the 3e Franco-Japonese DevBio meeting, from 7th to…\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sfbd.fr\/en\/2022\/11\/15\/prix-de-these-sfbd-2022-dr-helene-vignes\/\" \/>\n<meta property=\"og:site_name\" content=\"SFBD\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-15T10:55:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-11-15T12:48:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sfbd.fr\/wp-content\/uploads\/2022\/11\/image_coeur_Vecad-flidsRed-48hpf-scaled-e1668516064582.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"2560\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@sfbd_biodev\" \/>\n<meta name=\"twitter:site\" content=\"@sfbd_biodev\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"glenda comai\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Organization\",\"@id\":\"https:\/\/sfbd.fr\/en\/#organization\",\"name\":\"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement\",\"url\":\"https:\/\/sfbd.fr\/en\/\",\"sameAs\":[\"https:\/\/twitter.com\/sfbd_biodev\"],\"logo\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/sfbd.fr\/en\/#logo\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2019\/11\/Favicon.jpg\",\"contentUrl\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2019\/11\/Favicon.jpg\",\"width\":1324,\"height\":1324,\"caption\":\"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement\"},\"image\":{\"@id\":\"https:\/\/sfbd.fr\/en\/#logo\"}},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sfbd.fr\/en\/#website\",\"url\":\"https:\/\/sfbd.fr\/en\/\",\"name\":\"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/sfbd.fr\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sfbd.fr\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/sfbd.fr\/en\/2022\/11\/15\/prix-de-these-sfbd-2022-dr-helene-vignes\/#primaryimage\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2022\/11\/image_coeur_Vecad-flidsRed-48hpf-scaled-e1668516064582.jpg\",\"contentUrl\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2022\/11\/image_coeur_Vecad-flidsRed-48hpf-scaled-e1668516064582.jpg\",\"width\":2560,\"height\":2560},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sfbd.fr\/en\/2022\/11\/15\/prix-de-these-sfbd-2022-dr-helene-vignes\/#webpage\",\"url\":\"https:\/\/sfbd.fr\/en\/2022\/11\/15\/prix-de-these-sfbd-2022-dr-helene-vignes\/\",\"name\":\"Thesis Prize SFBD 2022: Dr. H\u00e9l\u00e8ne Vignes - 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The work of the winner:<\/h5>\n
H\u00e9l\u00e8ne Vignes exploited a remarkably interdisciplinary combination of genetics, modelling, imaging and cell biology techniques to study the formation of the atrio-ventricular canal (AVC), a region of the developing heart that gives rise to the cardiac valves. During development this structure is characterized by a higher cellular density than the surrounding regions of the developing heart. H\u00e9l\u00e8ne first showed that this is due to a significant cell volume decrease at the AVC region, then demonstrated that such a decrease in size is controlled by the mechanical forces generated by the cell microenvironment such as blood flow, heart contraction, ExtraCellular Matrix (ECM) composition. She even went on to identify several of the molecular players involved in this process and could show that Hyaluronic Acid, an ECM component, and two stretch-sensitive transmembrane channels, TRPP2 and TRPV4, are required to induce cell volume decrease.<\/p>\n
The jury considered that H\u00e9l\u00e8ne\u2019s work and the resulting publication are absolutely remarkable in that they underlie how multiple genetic, biochemical and mechanical cues orchestrate together the complex choreography of animal organogenesis. Besides, H\u00e9l\u00e8ne\u2019s thesis manuscript was considered exemplary for its exhaustivity, concision, clarity and accessibility.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_btn title=”Thesis Link” color=”black” link=”url:https%3A%2F%2Fwww.theses.fr%2Fs269491%23|target:_blank”][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] First prize : \u2192 Invitation to give a plenary lecture at the 3e Franco-Japonese DevBio meeting, from 7th to…<\/p>\n","protected":false},"author":6,"featured_media":10370,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"yoast_head":"\n