{"id":6386,"date":"2020-07-24T19:50:28","date_gmt":"2020-07-24T17:50:28","guid":{"rendered":"https:\/\/sfbd.fr\/?p=6386"},"modified":"2020-07-26T12:33:38","modified_gmt":"2020-07-26T10:33:38","slug":"cries-or-whispers-between-cells-during-ascidian-embryogenesis","status":"publish","type":"post","link":"https:\/\/sfbd.fr\/en\/2020\/07\/24\/cries-or-whispers-between-cells-during-ascidian-embryogenesis\/","title":{"rendered":"Cries or whispers between cells during ascidian embryogenesis"},"content":{"rendered":"\n<p>During embryonic development, as cells divide, they take on increasingly precise roles in the body. In most embryos, including our own, this process is reproducible at the tissue level, with the behaviour of individual cells varying from one embryo to another.<\/p>\n\n\n\n<p>In some embryos, however, including those of a small marine invertebrate, the sea squirt <em>Phallusia mammillata<\/em>, the reproducibility of embryonic development occurs at the cellular level: it is possible to name each cell and find a counterpart in each of the embryos of the species.<\/p>\n\n\n\n<p>In a work <a href=\"https:\/\/science.sciencemag.org\/content\/369\/6500\/eaar5663\">published<\/a> in the journal Science on July 10,  an intersdiciplinary team of CNRS, INRIA, and EMBL scientists led by <a href=\"http:\/\/www.crbm.cnrs.fr\/en\/team\/lemaire\/\" target=\"_blank\" rel=\"noreferrer noopener\">Patrick Lemaire,<\/a> <a href=\"https:\/\/team.inria.fr\/mosaic\/welcome\/team-members\/christophe-godin\/\" target=\"_blank\" rel=\"noreferrer noopener\">Christophe Godin<\/a> and <a href=\"http:\/\/www-sop.inria.fr\/members\/Gregoire.Malandain\/\" target=\"_blank\" rel=\"noreferrer noopener\">Gr\u00e9goire Malandain<\/a> systematically reconstructed over time the geometry and arrangement of each and every cell of living Phallusia mammillata embryos.<\/p>\n\n\n\n<p>Analysis of this dataset shows that embryogenesis is characterized by the lack of cell movements and apoptosis and a very high reproducibity between embryos, down to the subcellular scale of the surfaces of cell contact. Furthermore, the authors were able to link this reproducibility to an unusual mode of communication, by direct cell-to-cell contact.<\/p>\n\n\n\n<p>This work thus links the range of cellular signals and the scale, cellular or tissular, at which developmental reproducibility is observed.<\/p>\n\n\n\n<p>A <a rel=\"noreferrer noopener\" href=\"https:\/\/vimeo.com\/434433967\" target=\"_blank\">short animated video<\/a>, directed by <a rel=\"noreferrer noopener\" href=\"https:\/\/www.laurenceserfaty.com\/\" target=\"_blank\">Laurence Serfaty <\/a>and <a rel=\"noreferrer noopener\" href=\"https:\/\/vimeo.com\/user43448499\" target=\"_blank\">Isis Leterrier<\/a>, explains in non-specialist terms the scientific approach and the main results of this study.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>During embryonic development, as cells divide, they take on increasingly precise roles in the body. In most embryos, including our&hellip;<\/p>\n","protected":false},"author":4,"featured_media":6389,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[131],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cries or whispers between cells during ascidian embryogenesis - SFBD<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sfbd.fr\/en\/2020\/07\/24\/cries-or-whispers-between-cells-during-ascidian-embryogenesis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cries or whispers between cells during ascidian embryogenesis - SFBD\" \/>\n<meta property=\"og:description\" content=\"During embryonic development, as cells divide, they take on increasingly precise roles in the body. In most embryos, including our&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sfbd.fr\/en\/2020\/07\/24\/cries-or-whispers-between-cells-during-ascidian-embryogenesis\/\" \/>\n<meta property=\"og:site_name\" content=\"SFBD\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-24T17:50:28+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-26T10:33:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sfbd.fr\/wp-content\/uploads\/2020\/07\/Vignette.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1516\" \/>\n\t<meta property=\"og:image:height\" content=\"1276\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@sfbd_biodev\" \/>\n<meta name=\"twitter:site\" content=\"@sfbd_biodev\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Patrick Lemaire\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Organization\",\"@id\":\"https:\/\/sfbd.fr\/en\/#organization\",\"name\":\"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement\",\"url\":\"https:\/\/sfbd.fr\/en\/\",\"sameAs\":[\"https:\/\/twitter.com\/sfbd_biodev\"],\"logo\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/sfbd.fr\/en\/#logo\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2019\/11\/Favicon.jpg\",\"contentUrl\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2019\/11\/Favicon.jpg\",\"width\":1324,\"height\":1324,\"caption\":\"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement\"},\"image\":{\"@id\":\"https:\/\/sfbd.fr\/en\/#logo\"}},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sfbd.fr\/en\/#website\",\"url\":\"https:\/\/sfbd.fr\/en\/\",\"name\":\"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/sfbd.fr\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sfbd.fr\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/sfbd.fr\/en\/2020\/07\/24\/cries-or-whispers-between-cells-during-ascidian-embryogenesis\/#primaryimage\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2020\/07\/Vignette.jpg\",\"contentUrl\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2020\/07\/Vignette.jpg\",\"width\":1516,\"height\":1276},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sfbd.fr\/en\/2020\/07\/24\/cries-or-whispers-between-cells-during-ascidian-embryogenesis\/#webpage\",\"url\":\"https:\/\/sfbd.fr\/en\/2020\/07\/24\/cries-or-whispers-between-cells-during-ascidian-embryogenesis\/\",\"name\":\"Cries or whispers between cells during ascidian embryogenesis - 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Our overall goal is to bridge the molecular and cellular scales of analysis in order to provide an integrated view of a developmental program in time and space and to study its evolution. We first made use of the stereotyped and highly conserved cell lineage of ascidian embryos to decipher in detail their early transcriptional developmental program (Cell, 2003; Development 2006, 2007; Current Biology 2010). To understand how the lineage and morphogenetic program could be so well conserved in spite of extensive genomic divergence between ascidian species, we studied the architecture of ascidian cis-regulatory sequences and showed that is was flexible and robust to extensive TF binding site turnover (Development, 2005; Current Biology 2010; bioRxiv 2016). Thanks to the transparency of ascidian embryos, we could image and quantitatively describe early ascidian morphogenesis with cellular resolution (Current Biology, 2006; Science, 2020), and use this description to provide a molecular and mechanical model for the invagination of the endoderm at the beginning of gastrulation (Current Biology, 2010; Development 2020). To efficiently integrate heterogeneous datasets ranging from gene expression data to quantitative geometric descriptions of cell and tissue morphologies, we developed an integrative model organism database (ANISEED, Genome Research, 2010, Nucleic Acid Research 2016, 2018), which is the main database in the tunicate field. 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Our current work focuses on the comparison of the transcriptional (Developmental Biology, 2019) and morphogenetic (Science 2020) programs of distantly related ascidians, whose genomes we recently sequenced and annotated.","sameAs":["https:\/\/www.crbm.cnrs.fr\/patrick-lemaire\/?lang=en"],"url":"https:\/\/sfbd.fr\/en\/author\/patricklemaire\/"}]}},"_links":{"self":[{"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/posts\/6386"}],"collection":[{"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/comments?post=6386"}],"version-history":[{"count":5,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/posts\/6386\/revisions"}],"predecessor-version":[{"id":6403,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/posts\/6386\/revisions\/6403"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/media\/6389"}],"wp:attachment":[{"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/media?parent=6386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/categories?post=6386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/tags?post=6386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}