{"id":6629,"date":"2020-09-25T17:11:54","date_gmt":"2020-09-25T15:11:54","guid":{"rendered":"https:\/\/sfbd.fr\/2020\/09\/25\/master-internship-in-paris\/"},"modified":"2021-07-07T16:25:52","modified_gmt":"2021-07-07T14:25:52","slug":"master-internship-in-paris","status":"publish","type":"post","link":"https:\/\/sfbd.fr\/en\/2020\/09\/25\/master-internship-in-paris\/","title":{"rendered":"Master Internship in Paris"},"content":{"rendered":"
Adult organisms are generally defined by two properties: their size and their shape. These two properties are acquired thanks to two fundamental processes: growth and morphogenesis. Within a specie, individuals of different sizes share a similar shape. This suggests the existence of a coupling between morphogenesis and growth mechanisms. Uncovering these mechanisms remains a major question in developmental biology.<\/h6>\n

In the lab, we use the Drosophila <\/em>epithelium as a model to study morphogenesis. We have developed imaging of live-animals for extended periods of time (24h+ hours) combined with cutting-edge image processing and image analysis techniques. These methods allow us the observe the development of multiple animals at a multiscale resolution. Using these techniques, we have been able to decipher the mechanisms of proliferation in epithelial tissues1\u20134<\/sup>\u00a0 and how gene expression controls the shaping of tissue5,6<\/sup>. These knowledge and methods now offer the possibility to address the fundamental link between size and shape.<\/p>\n

This internship is based on a new and promising subject of our lab and supported by a large quantity of preliminary data. The student will be taught how to perform state-of-the-art live-imaging experiments and how to use the powerful genetic tools available in Drosophila <\/em>to bring together quantitative analysis, physiology, and tissue dynamics. The student will also benefit from the interdisciplinary expertise of the lab and the most-recent equipment available on the Institut Curie platforms.<\/p>\n

For more information, you can visit our lab website<\/a> and our lab twitter account<\/a>.<\/p>\n

If you are interested, please contact Aude Maugarny-Cal\u00e8s<\/a> and Yohanns Bella\u00efche<\/a> with a motivation letter and a CV.<\/p>\n

    \n
  1. L\u00f3pez-Gay, J. et al. Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue. Science.<\/strong> In Press<\/li>\n
  2. Pinheiro, D. et al. Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows. Nature<\/strong> 545, 103\u2013107 (2017).<\/li>\n
  3. Bosveld, F. et al. Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis. Nature<\/strong> 530, 1\u201322 (2016).<\/li>\n
  4. Herszterg, S., Leibfried, A., Bosveld, F., Martin, C. & Bellaiche, Y. Interplay between the Dividing Cell and Its Neighbors Regulates Adherens Junction Formation during Cytokinesis in Epithelial Tissue. Dev. Cell<\/strong> 24, 256\u2013270 (2013).<\/li>\n
  5. Bosveld, F. et al. Mechanical Control of Morphogenesis by Fat\/Dachsous\/Four-Jointed Planar Cell Polarity Pathway. Science<\/strong>. 336, 724\u2013727 (2012).<\/li>\n
  6. Guirao, B. et al. Unified quantitative characterization of epithelial tissue development. Elife<\/strong> 4, e08519 (2015).<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    to study the relationship between size and shape during development<\/p>\n","protected":false},"author":7,"featured_media":6625,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[93],"tags":[142],"yoast_head":"\nMaster Internship in Paris to study morphogenesis in Drosophila epithelium<\/title>\n<meta name=\"description\" content=\"This internship is based on a new and promising subject of our lab and supported by a large quantity of preliminary data.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sfbd.fr\/en\/2020\/09\/25\/master-internship-in-paris\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Master Internship in Paris to study morphogenesis in Drosophila epithelium\" \/>\n<meta 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