{"id":8295,"date":"2021-05-16T09:14:13","date_gmt":"2021-05-16T07:14:13","guid":{"rendered":"https:\/\/sfbd.fr\/2021\/05\/16\/phd-fellowship-lyon-france\/"},"modified":"2021-10-08T09:46:35","modified_gmt":"2021-10-08T07:46:35","slug":"phd-fellowship-lyon-france","status":"publish","type":"post","link":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/","title":{"rendered":"PhD fellowship (Lyon, France)"},"content":{"rendered":"\r\n

Developmental phenotypic plasticity in water striders<\/em><\/strong><\/p>\r\n\r\n\r\n\r\n

Where: <\/strong>The Khila lab at the Institute of Functional Genomics, \u00c9cole Normale Sup\u00e9rieure de Lyon, UMR CNRS 5242, Lyon, France<\/p>\r\n\r\n\r\n\r\n

http:\/\/igfl.ens-lyon.fr\/<\/a><\/p>\r\n\r\n\r\n\r\n

http:\/\/igfl.ens-lyon.fr\/equipes\/a.-khila-developmental-genomics-and-evolution<\/a><\/p>\r\n\r\n\r\n\r\n

Starting date: <\/strong>October 1st<\/sup>, 2021 or slightly after<\/p>\r\n\r\n\r\n\r\n

Deadline for applications:<\/strong> June 30th<\/sup>, 2021 (Only short-listed candidates will be notified).<\/p>\r\n\r\n\r\n\r\n

Project title: Molecular origin of extreme growth variation with focus on DNA methylation<\/strong><\/p>\r\n\r\n\r\n\r\n

Background: <\/strong>Growth variation under environmental influence is widespread in nature, yet our understanding of the underlying molecular mechanisms remains limited. This process, known as developmental phenotypic plasticity, provides an invaluable opportunity to understand the genotype-phenotype relationship and the impact of the environment on this relationship.<\/p>\r\n\r\n\r\n\r\n

Hypothesis:<\/strong> Variation in nutritional input causes extreme growth variation through changes in DNA methylation states and transcriptional regulation. This hypothesis is supported by preliminary data.<\/p>\r\n\r\n\r\n\r\n

Model system:<\/strong> We test this hypothesis in the water strider Microvelia longipes <\/em>(Image). The males have longer legs than females, but also extreme variation in hind-leg length between males. Our recent work showed that males use their hind legs as weapons during contests, and that long-legged males have significantly higher chance to dominate egg-laying sites and access females (Toubiana and Khila, Proc B. 2019<\/a><\/em>). We recently identified the gene BMP11<\/em> as a primary regulator of scaling relationships between the body and the hind-legs in a male-specific manner (Toubiana et al. PLoS Biology, 2021<\/a><\/em>). We also built the resources required for this project, including a high-quality genome and transcriptomes (Toubiana, Armisen et al. BMC Biology 2021<\/a><\/em>), isogenic lines and lab populations (easy to keep), DNA methylation datasets, as well as various developmental genetics tools (Toubiana et al. PLoS Biology, 2021<\/a><\/em>).<\/p>\r\n\r\n\r\n\r\n

Project:<\/strong> The successful PhD candidate will collaborate with a team of postdocs and lab technicians studying how variation in nutritional input causes extreme growth variation through changes in epigenetic states and transcriptional regulation. The objectives are:<\/p>\r\n\r\n\r\n\r\n

– Build the genome-wide methylome of this species (using Bisulfite sequencing and isogenic lines)<\/p>\r\n\r\n\r\n\r\n

– Determine the fraction of DNA methylation sites that responds to nutritional treatment<\/p>\r\n\r\n\r\n\r\n

– Determine the genes whose expression profiles correlate with changes in nutritional treatment and changes in DNA methylation states.<\/p>\r\n\r\n\r\n\r\n

– Functionally test (by RNAi or Crispr-Cas) a small selection of the loci identified above.<\/p>\r\n\r\n\r\n\r\n

Mandatory requirement:<\/strong> Master\u2019s degree (or equivalent).<\/p>\r\n\r\n\r\n\r\n

Concepts:<\/strong> Epigenetics, genetic variation, nutritional manipulation, developmental genetics<\/p>\r\n\r\n\r\n\r\n

Expertise we seek:<\/strong> DNA methylation analyses, Bioinformatics, Statistics, Programming in R<\/p>\r\n\r\n\r\n\r\n

Skills: <\/strong>Good English (written and spoken), motivation, creativity, curiosity, good work ethics, team-work, and good inter-personal relationship with colleagues. Knowledge in evolutionary biology, epigenetics or development is a plus.<\/p>\r\n\r\n\r\n\r\n

How to apply: <\/strong>By email to abderrahman.khila@ens-lyon.fr<\/a> with a motivation letter<\/strong> explaining why you are interested by this position and how you think you are qualified, your CV <\/strong>and names and e-mail addresses of two or three referees <\/strong>who can write letters of reference on your behalf.<\/p>\r\n","protected":false},"excerpt":{"rendered":"

Developmental phenotypic plasticity in water striders Where: The Khila lab at the Institute of Functional Genomics, \u00c9cole Normale Sup\u00e9rieure de…<\/p>\n","protected":false},"author":206,"featured_media":8281,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[93],"tags":[95],"yoast_head":"\nPhD fellowship (Lyon, France) - SFBD<\/title>\n<meta name=\"description\" content=\"Where: The Khila lab at the Institute of Functional Genomics, \u00c9cole Normale Sup\u00e9rieure de Lyon, UMR CNRS 5242, Lyon, Francehttp:\/\/igfl.ens-lyon.fr\/http:\/\/igfl.ens-lyon.fr\/equipes\/a.-khila-developmental-genomics-and-evolutionStarting date: October 1st, 2021 or slightly afterDeadline for applications: June 30th, 2021 (Only short-listed candidates will be notified).Project title: Molecular origin of extreme growth variation with focus on DNA methylationBackground: Growth variation under environmental influence is widespread in nature, yet our understanding of the underlying molecular mechanisms remains limited. This process, known as developmental phenotypic plasticity, provides an invaluable opportunity to understand the genotype-phenotype relationship and the impact of the environment on this relationship. Hypothesis: Variation in nutritional input causes extreme growth variation through changes in DNA methylation states and transcriptional regulation. This hypothesis is supported by preliminary data.Model system: We test this hypothesis in the water strider Microvelia longipes (Image). The males have longer legs than females, but also extreme variation in hind-leg length between males (Image). Our recent work showed that males use their hind legs as weapons during contests, and that long-legged males have significantly higher chance to dominate egg-laying sites and access females (Toubiana and Khila, Proc B. 2019). We recently identified the gene BMP11 as a primary regulator of scaling relationships between the body and the hind-legs in a male-specific manner (Toubiana et al. PLoS Biology, 2021). We also built the resources required for this project, including a high-quality genome and transcriptomes (Toubiana, Armisen et al. BMC Biology 2021), isogenic lines and lab populations (easy to keep), DNA methylation datasets, as well as various developmental genetics tools (Toubiana et al. PLoS Biology, 2021).Project: The successful PhD candidate will collaborate with a team of postdocs and lab technicians studying how variation in nutritional input causes extreme growth variation through changes in epigenetic states and transcriptional regulation. The objectives are:- Build the genome-wide methylome of this species (using Bisulfite sequencing and isogenic lines)- Determine the fraction of DNA methylation sites that responds to nutritional treatment- Determine the genes whose expression profiles correlate with changes in nutritional treatment and changes in DNA methylation states.- Functionally test (by RNAi or Crispr-Cas) a small selection of the loci identified above.Mandatory requirement: Master\u2019s degree (or equivalent).Concepts: Epigenetics, genetic variation, nutritional manipulation, developmental geneticsExpertise we seek: DNA methylation analyses, Bioinformatics, Statistics, Programming in RSkills: Good English (written and spoken), motivation, creativity, curiosity, good work ethics, team-work, and good inter-personal relationship with colleagues. Knowledge in evolutionary biology, epigenetics or development is a plus.How to apply: By email to abderrahman.khila@ens-lyon.fr with a motivation letter explaining why you are interested by this position and how you think you are qualified, your CV and names and e-mail addresses of two or three referees who can write letters of reference on your behalf.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PhD position (Lyon, France): Developmental phenotypic plasticity in water striders\" \/>\n<meta property=\"og:description\" content=\"Molecular origin of extreme growth variation with focus on DNA methylation\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/\" \/>\n<meta property=\"og:site_name\" content=\"SFBD\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-16T07:14:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-10-08T07:46:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sfbd.fr\/wp-content\/uploads\/2021\/05\/Microvelia_longipes_Variation.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"600\" \/>\n\t<meta property=\"og:image:height\" content=\"380\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"PhD position (Lyon, France): Developmental phenotypic plasticity in water striders\" \/>\n<meta name=\"twitter:description\" content=\"Molecular origin of extreme growth variation with focus on DNA methylation\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/sfbd.fr\/wp-content\/uploads\/2021\/05\/Microvelia_longipes_Variation.jpg\" \/>\n<meta name=\"twitter:creator\" content=\"@sfbd_biodev\" \/>\n<meta name=\"twitter:site\" content=\"@sfbd_biodev\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"abderrahman.khila@ens-lyon.fr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Organization\",\"@id\":\"https:\/\/sfbd.fr\/en\/#organization\",\"name\":\"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement\",\"url\":\"https:\/\/sfbd.fr\/en\/\",\"sameAs\":[\"https:\/\/twitter.com\/sfbd_biodev\"],\"logo\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/sfbd.fr\/en\/#logo\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2019\/11\/Favicon.jpg\",\"contentUrl\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2019\/11\/Favicon.jpg\",\"width\":1324,\"height\":1324,\"caption\":\"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement\"},\"image\":{\"@id\":\"https:\/\/sfbd.fr\/en\/#logo\"}},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sfbd.fr\/en\/#website\",\"url\":\"https:\/\/sfbd.fr\/en\/\",\"name\":\"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/sfbd.fr\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sfbd.fr\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#primaryimage\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2021\/05\/Microvelia_longipes_Variation.jpg\",\"contentUrl\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2021\/05\/Microvelia_longipes_Variation.jpg\",\"width\":600,\"height\":380},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#webpage\",\"url\":\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/\",\"name\":\"PhD fellowship (Lyon, France) - SFBD\",\"isPartOf\":{\"@id\":\"https:\/\/sfbd.fr\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#primaryimage\"},\"datePublished\":\"2021-05-16T07:14:13+00:00\",\"dateModified\":\"2021-10-08T07:46:35+00:00\",\"description\":\"Where: The Khila lab at the Institute of Functional Genomics, \u00c9cole Normale Sup\u00e9rieure de Lyon, UMR CNRS 5242, Lyon, Francehttp:\/\/igfl.ens-lyon.fr\/http:\/\/igfl.ens-lyon.fr\/equipes\/a.-khila-developmental-genomics-and-evolutionStarting date: October 1st, 2021 or slightly afterDeadline for applications: June 30th, 2021 (Only short-listed candidates will be notified).Project title: Molecular origin of extreme growth variation with focus on DNA methylationBackground: Growth variation under environmental influence is widespread in nature, yet our understanding of the underlying molecular mechanisms remains limited. This process, known as developmental phenotypic plasticity, provides an invaluable opportunity to understand the genotype-phenotype relationship and the impact of the environment on this relationship. Hypothesis: Variation in nutritional input causes extreme growth variation through changes in DNA methylation states and transcriptional regulation. This hypothesis is supported by preliminary data.Model system: We test this hypothesis in the water strider Microvelia longipes (Image). The males have longer legs than females, but also extreme variation in hind-leg length between males (Image). Our recent work showed that males use their hind legs as weapons during contests, and that long-legged males have significantly higher chance to dominate egg-laying sites and access females (Toubiana and Khila, Proc B. 2019). We recently identified the gene BMP11 as a primary regulator of scaling relationships between the body and the hind-legs in a male-specific manner (Toubiana et al. PLoS Biology, 2021). We also built the resources required for this project, including a high-quality genome and transcriptomes (Toubiana, Armisen et al. BMC Biology 2021), isogenic lines and lab populations (easy to keep), DNA methylation datasets, as well as various developmental genetics tools (Toubiana et al. PLoS Biology, 2021).Project: The successful PhD candidate will collaborate with a team of postdocs and lab technicians studying how variation in nutritional input causes extreme growth variation through changes in epigenetic states and transcriptional regulation. The objectives are:- Build the genome-wide methylome of this species (using Bisulfite sequencing and isogenic lines)- Determine the fraction of DNA methylation sites that responds to nutritional treatment- Determine the genes whose expression profiles correlate with changes in nutritional treatment and changes in DNA methylation states.- Functionally test (by RNAi or Crispr-Cas) a small selection of the loci identified above.Mandatory requirement: Master\u2019s degree (or equivalent).Concepts: Epigenetics, genetic variation, nutritional manipulation, developmental geneticsExpertise we seek: DNA methylation analyses, Bioinformatics, Statistics, Programming in RSkills: Good English (written and spoken), motivation, creativity, curiosity, good work ethics, team-work, and good inter-personal relationship with colleagues. Knowledge in evolutionary biology, epigenetics or development is a plus.How to apply: By email to abderrahman.khila@ens-lyon.fr with a motivation letter explaining why you are interested by this position and how you think you are qualified, your CV and names and e-mail addresses of two or three referees who can write letters of reference on your behalf.\",\"breadcrumb\":{\"@id\":\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/sfbd.fr\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"PhD fellowship (Lyon, France)\"}]},{\"@type\":\"Article\",\"@id\":\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#webpage\"},\"author\":{\"@id\":\"https:\/\/sfbd.fr\/en\/#\/schema\/person\/bcc2cc9029c7fc93a37226c27e73788d\"},\"headline\":\"PhD fellowship (Lyon, France)\",\"datePublished\":\"2021-05-16T07:14:13+00:00\",\"dateModified\":\"2021-10-08T07:46:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#webpage\"},\"wordCount\":479,\"publisher\":{\"@id\":\"https:\/\/sfbd.fr\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/sfbd.fr\/wp-content\/uploads\/2021\/05\/Microvelia_longipes_Variation.jpg\",\"keywords\":[\"PhD\"],\"articleSection\":[\"Job opportunities\"],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/sfbd.fr\/en\/#\/schema\/person\/bcc2cc9029c7fc93a37226c27e73788d\",\"name\":\"abderrahman.khila@ens-lyon.fr\",\"image\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/sfbd.fr\/en\/#personlogo\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/6a677957618e35c7a6eca12b2585823c?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/6a677957618e35c7a6eca12b2585823c?s=96&d=mm&r=g\",\"caption\":\"abderrahman.khila@ens-lyon.fr\"},\"url\":\"https:\/\/sfbd.fr\/en\/author\/abderrahman-khilaens-lyon-fr\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"PhD fellowship (Lyon, France) - SFBD","description":"Where: The Khila lab at the Institute of Functional Genomics, \u00c9cole Normale Sup\u00e9rieure de Lyon, UMR CNRS 5242, Lyon, Francehttp:\/\/igfl.ens-lyon.fr\/http:\/\/igfl.ens-lyon.fr\/equipes\/a.-khila-developmental-genomics-and-evolutionStarting date: October 1st, 2021 or slightly afterDeadline for applications: June 30th, 2021 (Only short-listed candidates will be notified).Project title: Molecular origin of extreme growth variation with focus on DNA methylationBackground: Growth variation under environmental influence is widespread in nature, yet our understanding of the underlying molecular mechanisms remains limited. This process, known as developmental phenotypic plasticity, provides an invaluable opportunity to understand the genotype-phenotype relationship and the impact of the environment on this relationship. Hypothesis: Variation in nutritional input causes extreme growth variation through changes in DNA methylation states and transcriptional regulation. This hypothesis is supported by preliminary data.Model system: We test this hypothesis in the water strider Microvelia longipes (Image). The males have longer legs than females, but also extreme variation in hind-leg length between males (Image). Our recent work showed that males use their hind legs as weapons during contests, and that long-legged males have significantly higher chance to dominate egg-laying sites and access females (Toubiana and Khila, Proc B. 2019). We recently identified the gene BMP11 as a primary regulator of scaling relationships between the body and the hind-legs in a male-specific manner (Toubiana et al. PLoS Biology, 2021). We also built the resources required for this project, including a high-quality genome and transcriptomes (Toubiana, Armisen et al. BMC Biology 2021), isogenic lines and lab populations (easy to keep), DNA methylation datasets, as well as various developmental genetics tools (Toubiana et al. PLoS Biology, 2021).Project: The successful PhD candidate will collaborate with a team of postdocs and lab technicians studying how variation in nutritional input causes extreme growth variation through changes in epigenetic states and transcriptional regulation. The objectives are:- Build the genome-wide methylome of this species (using Bisulfite sequencing and isogenic lines)- Determine the fraction of DNA methylation sites that responds to nutritional treatment- Determine the genes whose expression profiles correlate with changes in nutritional treatment and changes in DNA methylation states.- Functionally test (by RNAi or Crispr-Cas) a small selection of the loci identified above.Mandatory requirement: Master\u2019s degree (or equivalent).Concepts: Epigenetics, genetic variation, nutritional manipulation, developmental geneticsExpertise we seek: DNA methylation analyses, Bioinformatics, Statistics, Programming in RSkills: Good English (written and spoken), motivation, creativity, curiosity, good work ethics, team-work, and good inter-personal relationship with colleagues. Knowledge in evolutionary biology, epigenetics or development is a plus.How to apply: By email to abderrahman.khila@ens-lyon.fr with a motivation letter explaining why you are interested by this position and how you think you are qualified, your CV and names and e-mail addresses of two or three referees who can write letters of reference on your behalf.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/","og_locale":"en_US","og_type":"article","og_title":"PhD position (Lyon, France): Developmental phenotypic plasticity in water striders","og_description":"Molecular origin of extreme growth variation with focus on DNA methylation","og_url":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/","og_site_name":"SFBD","article_published_time":"2021-05-16T07:14:13+00:00","article_modified_time":"2021-10-08T07:46:35+00:00","og_image":[{"width":600,"height":380,"url":"https:\/\/sfbd.fr\/wp-content\/uploads\/2021\/05\/Microvelia_longipes_Variation.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_title":"PhD position (Lyon, France): Developmental phenotypic plasticity in water striders","twitter_description":"Molecular origin of extreme growth variation with focus on DNA methylation","twitter_image":"https:\/\/sfbd.fr\/wp-content\/uploads\/2021\/05\/Microvelia_longipes_Variation.jpg","twitter_creator":"@sfbd_biodev","twitter_site":"@sfbd_biodev","twitter_misc":{"Written by":"abderrahman.khila@ens-lyon.fr","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Organization","@id":"https:\/\/sfbd.fr\/en\/#organization","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement","url":"https:\/\/sfbd.fr\/en\/","sameAs":["https:\/\/twitter.com\/sfbd_biodev"],"logo":{"@type":"ImageObject","@id":"https:\/\/sfbd.fr\/en\/#logo","inLanguage":"en-US","url":"https:\/\/sfbd.fr\/wp-content\/uploads\/2019\/11\/Favicon.jpg","contentUrl":"https:\/\/sfbd.fr\/wp-content\/uploads\/2019\/11\/Favicon.jpg","width":1324,"height":1324,"caption":"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement"},"image":{"@id":"https:\/\/sfbd.fr\/en\/#logo"}},{"@type":"WebSite","@id":"https:\/\/sfbd.fr\/en\/#website","url":"https:\/\/sfbd.fr\/en\/","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Biologie du D\u00e9veloppement","description":"","publisher":{"@id":"https:\/\/sfbd.fr\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sfbd.fr\/en\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"ImageObject","@id":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#primaryimage","inLanguage":"en-US","url":"https:\/\/sfbd.fr\/wp-content\/uploads\/2021\/05\/Microvelia_longipes_Variation.jpg","contentUrl":"https:\/\/sfbd.fr\/wp-content\/uploads\/2021\/05\/Microvelia_longipes_Variation.jpg","width":600,"height":380},{"@type":"WebPage","@id":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#webpage","url":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/","name":"PhD fellowship (Lyon, France) - SFBD","isPartOf":{"@id":"https:\/\/sfbd.fr\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#primaryimage"},"datePublished":"2021-05-16T07:14:13+00:00","dateModified":"2021-10-08T07:46:35+00:00","description":"Where: The Khila lab at the Institute of Functional Genomics, \u00c9cole Normale Sup\u00e9rieure de Lyon, UMR CNRS 5242, Lyon, Francehttp:\/\/igfl.ens-lyon.fr\/http:\/\/igfl.ens-lyon.fr\/equipes\/a.-khila-developmental-genomics-and-evolutionStarting date: October 1st, 2021 or slightly afterDeadline for applications: June 30th, 2021 (Only short-listed candidates will be notified).Project title: Molecular origin of extreme growth variation with focus on DNA methylationBackground: Growth variation under environmental influence is widespread in nature, yet our understanding of the underlying molecular mechanisms remains limited. This process, known as developmental phenotypic plasticity, provides an invaluable opportunity to understand the genotype-phenotype relationship and the impact of the environment on this relationship. Hypothesis: Variation in nutritional input causes extreme growth variation through changes in DNA methylation states and transcriptional regulation. This hypothesis is supported by preliminary data.Model system: We test this hypothesis in the water strider Microvelia longipes (Image). The males have longer legs than females, but also extreme variation in hind-leg length between males (Image). Our recent work showed that males use their hind legs as weapons during contests, and that long-legged males have significantly higher chance to dominate egg-laying sites and access females (Toubiana and Khila, Proc B. 2019). We recently identified the gene BMP11 as a primary regulator of scaling relationships between the body and the hind-legs in a male-specific manner (Toubiana et al. PLoS Biology, 2021). We also built the resources required for this project, including a high-quality genome and transcriptomes (Toubiana, Armisen et al. BMC Biology 2021), isogenic lines and lab populations (easy to keep), DNA methylation datasets, as well as various developmental genetics tools (Toubiana et al. PLoS Biology, 2021).Project: The successful PhD candidate will collaborate with a team of postdocs and lab technicians studying how variation in nutritional input causes extreme growth variation through changes in epigenetic states and transcriptional regulation. The objectives are:- Build the genome-wide methylome of this species (using Bisulfite sequencing and isogenic lines)- Determine the fraction of DNA methylation sites that responds to nutritional treatment- Determine the genes whose expression profiles correlate with changes in nutritional treatment and changes in DNA methylation states.- Functionally test (by RNAi or Crispr-Cas) a small selection of the loci identified above.Mandatory requirement: Master\u2019s degree (or equivalent).Concepts: Epigenetics, genetic variation, nutritional manipulation, developmental geneticsExpertise we seek: DNA methylation analyses, Bioinformatics, Statistics, Programming in RSkills: Good English (written and spoken), motivation, creativity, curiosity, good work ethics, team-work, and good inter-personal relationship with colleagues. Knowledge in evolutionary biology, epigenetics or development is a plus.How to apply: By email to abderrahman.khila@ens-lyon.fr with a motivation letter explaining why you are interested by this position and how you think you are qualified, your CV and names and e-mail addresses of two or three referees who can write letters of reference on your behalf.","breadcrumb":{"@id":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/sfbd.fr\/en\/"},{"@type":"ListItem","position":2,"name":"PhD fellowship (Lyon, France)"}]},{"@type":"Article","@id":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#article","isPartOf":{"@id":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#webpage"},"author":{"@id":"https:\/\/sfbd.fr\/en\/#\/schema\/person\/bcc2cc9029c7fc93a37226c27e73788d"},"headline":"PhD fellowship (Lyon, France)","datePublished":"2021-05-16T07:14:13+00:00","dateModified":"2021-10-08T07:46:35+00:00","mainEntityOfPage":{"@id":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#webpage"},"wordCount":479,"publisher":{"@id":"https:\/\/sfbd.fr\/en\/#organization"},"image":{"@id":"https:\/\/sfbd.fr\/en\/2021\/05\/16\/phd-fellowship-lyon-france\/#primaryimage"},"thumbnailUrl":"https:\/\/sfbd.fr\/wp-content\/uploads\/2021\/05\/Microvelia_longipes_Variation.jpg","keywords":["PhD"],"articleSection":["Job opportunities"],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/sfbd.fr\/en\/#\/schema\/person\/bcc2cc9029c7fc93a37226c27e73788d","name":"abderrahman.khila@ens-lyon.fr","image":{"@type":"ImageObject","@id":"https:\/\/sfbd.fr\/en\/#personlogo","inLanguage":"en-US","url":"https:\/\/secure.gravatar.com\/avatar\/6a677957618e35c7a6eca12b2585823c?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6a677957618e35c7a6eca12b2585823c?s=96&d=mm&r=g","caption":"abderrahman.khila@ens-lyon.fr"},"url":"https:\/\/sfbd.fr\/en\/author\/abderrahman-khilaens-lyon-fr\/"}]}},"_links":{"self":[{"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/posts\/8295"}],"collection":[{"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/users\/206"}],"replies":[{"embeddable":true,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/comments?post=8295"}],"version-history":[{"count":2,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/posts\/8295\/revisions"}],"predecessor-version":[{"id":8856,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/posts\/8295\/revisions\/8856"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/media\/8281"}],"wp:attachment":[{"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/media?parent=8295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/categories?post=8295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sfbd.fr\/en\/wp-json\/wp\/v2\/tags?post=8295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}