SFBD
  • Offcanvas Icon
    • Home
    • Qui sommes-nous ?
      • Adhérer
      • Adhérents
      • Sponsors
      • Sociétés partenaires
    • Actions
      • Bourses de voyage
      • Prix de thèse
      • Soutiens aux évènements
      • Prises de position
    • Actualités
    • Emplois
    • Agenda
    • Ressources
    • Formation
      • Masters
      • Écoles doctorales
      • Cours internationaux
      • Venir en France
    • Galerie d’images
    • Menu Offcanvas Sidebar
  • ADHÉRER
  • CONNEXION / INSCRIPTION
  • FAQ’s
  • Français
  • Anglais
SFBD
  • La SFBD
    • Qui sommes-nous ?
    • Adhérer
    • Adhérents
    • Sociétés partenaires
    • Sponsors
    • Contact
  • Actions
    • Prix de thèse
    • Bourses de voyage
    • Soutiens aux événements
    • Bourses de transition de carrière
    • Prises de position
  • Actualités
    • Actualités
    • Poster une actualité
    • Tutoriel « poster une actualité »
    • La lettre de la SFBD
  • Emplois
    • Offres d’emploi / stage
    • Poster une offre d’emploi / stage
    • Tutoriel « poster une offre d’emploi »
  • Agenda
  • Ressources
    • Evènements en ligne
    • Médiation
    • Ressources d’enseignement
    • Ressources à destination d’un public averti
    • Bases de données modèles d’étude
    • Groupements de Recherche (GdR)
    • Impact Environnemental
    • Réseaux Inclusifs
  • Formations
    • Masters
    • Écoles doctorales
    • Cours internationaux
    • MOOCS
    • Venir en France
  • Galerie

2-year post-doctoral funding: robustness of ascidian embryogenesis to environmental and experimental variation

Page d'accueil Emploi 2-year post-doctoral funding: robustness of ascidian embryogenesis to environmental and experimental variation
Emploi

2-year post-doctoral funding: robustness of ascidian embryogenesis to environmental and experimental variation

1 avril 2022
By Patrick Lemaire
0 Comment
1272 Views

The tunicate team at CRBM (Montpellier, France), headed by Patrick Lemaire, is offering a 2-year post-doctoral fellowship (or a 3-year PhD fellowship for an exceptional candidate) to study the robustness of animal embryonic development to genetic and environmental perturbations, using quantitative live imaging of ascidian embryos. A short video describes a recent piece of work of the team relevant to the project.

Why ascidians?

Ascidians are a group of marine invertebrates. Their embryonic cell lineages and early embryonic stage morphologies have remained essentially identical since the group’s emergence about 400 million years ago. This suggests that they are subject to very strong developmental or evolutionary constraints (Lemaire et al. 2011). Ascidian embryogenesis is also very robust to environmental perturbations of temperature and salinity. The extreme evolutionary and environmental robustness of embryonic geometries and cell lineages contrasts with a rapid genetic divergence between species and intra- and inter-specific variability in gene expression.

What is the project?

The proposed experimental project will provide a quantitative assessment of the developmental robustness of a critical morphogenetic process, ascidian gastrulation (1, 3, 5), to two key environmental parameters (water temperature and salinity) and to genetic perturbations of the morphogenetic driving force apparatus (myosin II, Rho kinase, …). The project will study the magnitude of environmental or genetic variations compatible with the production of a viable larva. It will seek to identify the least – and most – robust developmental processes and time points, i. e. those that collapse first, or resist best to the perturbations. Finally, it will characterize the structure of the natural and experimentally-induced variability in the geometry and mechanical properties of embryos. This may lead to the identification of developmental modules.

The project will involve advanced light-sheet imaging of live micro-injected embryos of the ascidian Phallusia mammillata, followed by the computational and statistical analysis of the acquired developmental movies (see 2, 4).

Who funds the project, and how to apply?

The project is funded by an ANR-NSF binational project grant and will be conducted in collaboration with 3 other teams: Prof. Atef Asnacios (MSC, Paris), Prof. Edwin Munro (U. Chicago, USA) and Prof. Madhav Mani (Northwestern University, Evanston, USA).

Expected candidates will have a PhD in cell and developmental biology, an excellent track record of publications and oral communications, strong skills in fluorescent live imaging and some experience in the computational analysis of large datasets. To apply, send Patrick Lemaire (patrick.lemaire[at]crbm.cnrs.fr) by May 11, 2022 at the latest a motivation letter, a CV and the names and contact details of 2 academic referees including the PhD supervisor. A working knowledge of English (B2) is needed, there is no prerequisite in French.

References
  1. Fiuza U.-M. and Lemaire, P. (2021) Mechanical and genetic control of ascidian endoderm invagination during gastrulation, Semin Cell Dev Biol 120:108-118
  2. Guignard L. *, Fiuza U.-M. *, Leggio B., Laussu J., Faure E., Michelin G., Biasuz K., Hufnagel L., Malandain G. #, Godin C. #, Lemaire P.# (2020) Contact-area dependent cell communications and the morphological invariance of ascidian embryogenesis. Science, 369 :6500 eaar5663
  3. Fiuza U-M, Negishi T., Rouan A., Yasuo H.#, Lemaire P. # (2020) Nodal and Eph signalling relay drives the transition between apical constriction and apico-basal shortening during ascidian endoderm invagination. Development 147: dev186965
  4. Leggio, B; Laussu J; Carlier, A; Godin, C; Lemaire, P and Faure, E (2019) MorphoNet: An interactive online morphological browser to explore complex multi-scale data. Nat Commun. 10(1):2812
  5. Lemaire P. (2011) Evolutionary crossroads in developmental biology: the tunicates, Development, 138(11):2143-52
  6. Sherrard, K., Robin, FB, Lemaire, P., and Munro, E. (2010) Sequential activation of apical and basolateral myosin drives endoderm invagination during ascidian gastrulation, Current Biology, 20(17):1499-510.
Tags: ascidian embryo evolution imaging job robustness variability

Previous Story
La biologie cellulaire, développementale et évolutive face aux changements environnementaux : leçons et impacts
Next Story
PhD project: Multi-scale computational analysis of embryonic variability in ascidians

Postez vos annonces

Tous les adhérents peuvent publier leurs annonces en se connectant à leur compte.

→ Vous n’êtes pas encore adhérents ? Adhérer directement en ligne
Formulaire d’adhésion

→ Adhérents mais pas encore de compte de connexion ? Inscrivez-vous !
Inscription

Toutes les actualités

Archives

  • mai 2022 (3)
  • avril 2022 (5)
  • mars 2022 (3)
  • janvier 2022 (8)
  • novembre 2021 (7)
  • octobre 2021 (4)
  • septembre 2021 (2)
  • août 2021 (1)
  • juillet 2021 (2)
  • juin 2021 (2)
  • mai 2021 (14)
  • avril 2021 (25)
  • mars 2021 (2)
  • février 2021 (2)
  • janvier 2021 (1)
  • décembre 2020 (5)
  • novembre 2020 (4)
  • octobre 2020 (9)
  • septembre 2020 (2)
  • août 2020 (3)
  • juillet 2020 (2)
  • juin 2020 (7)
  • mai 2020 (4)
  • avril 2020 (2)
  • mars 2020 (3)
  • février 2020 (5)
  • janvier 2020 (3)
  • décembre 2019 (3)
  • novembre 2019 (5)
  • octobre 2019 (4)
  • septembre 2019 (2)
  • août 2019 (1)
  • juillet 2019 (4)
  • juin 2019 (4)
  • mai 2019 (2)
  • avril 2019 (1)
  • mars 2019 (2)
  • décembre 2018 (7)
  • novembre 2018 (6)
  • octobre 2018 (4)
  • septembre 2018 (1)
  • août 2018 (1)
  • juillet 2018 (1)
  • juin 2018 (4)

La SFBD sur Twitter

SFBD-BioDevFollow

Official account of the French Society for Developmental Biology

Avatar
Retweet on TwitterSFBD-BioDev Retweeted
AvatarBritish Society for Developmental Biology@_BSDB_·
24 Mai

We are proud to support this very special two-day meeting celebrating the life of Lewis Wolpert.

13-14 Sept 2022, in London and online.

Register now to attend one or both days, in person or online. Attendance is free for all.

https://www.eventbrite.co.uk/e/in-memory-of-lewis-wolpert-tickets-168940620945

Please spread the word!

Reply on Twitter 1529102394801508353Retweet on Twitter 152910239480150835341Like on Twitter 152910239480150835349Twitter 1529102394801508353
AvatarSFBD-BioDev@sfbd_biodev·
23 Mai

The @bellaiche_y lab is looking for a research engineer / lab manager. Apply before June 15th. https://sfbd.fr/en/2022/05/23/poste-dingenieur-de-recherche-institut-curie-paris/

Reply on Twitter 1528640633572888576Retweet on Twitter 1528640633572888576Like on Twitter 15286406335728885762Twitter 1528640633572888576
Retweet on TwitterSFBD-BioDev Retweeted
AvatarMaria Leptin@mleptin·
18 Mai

amazing discussion - both Claudio's and Alex's points. I find DevBio exciting and VERY painful to leave behind. But why are there so few applications to the ERC? It's now one of the smallest fields in LifeScience - not in terms of awards but in applications. https://twitter.com/schierlab/status/1526132544177115141

Alex Schier@schierlab

Sad to see that one of my heroes bemoans the erosion of Developmental Biology. In fact the field has undergone a renaissance and is now in a golden age due to new talent, new technologies and new ideas. In just the past few weeks, amazing findings have been reported…..1/n

Reply on Twitter 1527058841267060736Retweet on Twitter 15270588412670607366Like on Twitter 152705884126706073624Twitter 1527058841267060736
Load More...

SOCIÉTÉ FRANÇAISE DE BIOLOGIE DU DÉVELOPPEMENT

Contact  Twitter

ILS SPONSORISENT LA SFBD

Copyright ©2019 Société Française de Biologie du Développement. All Rights Reserved. Webmaster Bioself Communication. Logo by Melanie Roussat.
SearchPostsLogin
lundi, 23, Mai
Poste d’Ingénieur de recherche, Institut Curie, Paris
mardi, 17, Mai
Julien Leclercq, San Antonio, Texas, 28 février au 4 mars 2022
mardi, 3, Mai
Postdoctoral Position on Epithelial Tissue Morphogenesis
vendredi, 8, Avr
18ème journée du Club Développement des Réseaux Neuronaux
jeudi, 7, Avr
EMBO Practical Course: C. elegans: from genome editing to imaging 17 – 23 July 2022
mercredi, 6, Avr
Offre CDD un an technicien en génétique moléculaire

Welcome back,