SFBD
  • Offcanvas Icon
    • Home
    • Qui sommes-nous ?
      • Adhérer
      • Adhérents
      • Sponsors
      • Sociétés partenaires
    • Actions
      • Bourses de voyage
      • Prix de thèse
      • Soutiens aux évènements
      • Prises de position
    • Actualités
    • Emplois
    • Agenda
    • Ressources
    • Formation
      • Masters
      • Écoles doctorales
      • Cours internationaux
      • Venir en France
    • Galerie d’images
    • Menu Offcanvas Sidebar
  • ADHÉRER
  • CONNEXION / INSCRIPTION
  • FAQ’s
  • Français
  • Anglais
SFBD
  • La SFBD
    • Qui sommes-nous ?
    • Adhérer
    • Adhérents
    • Sociétés partenaires
    • Sponsors
    • Contact
  • Actions
    • Prix de thèse
    • Bourses de voyage
    • Soutiens aux événements
    • Prises de position
  • Actualités
    • Actualités
    • Poster une actualité
    • Tutoriel « poster une actualité »
    • La lettre de la SFBD
  • Emplois
    • Offres d’emploi / stage
    • Poster une offre d’emploi / stage
    • Tutoriel « poster une offre d’emploi »
  • Agenda
  • Ressources
    • Evènements en ligne
    • Médiation
    • Ressources d’enseignement
    • Ressources à destination d’un public averti
    • Bases de données modèles d’étude
    • Groupements de Recherche (GdR)
    • Impact Environnemental
    • Réseaux Inclusifs
  • Formations
    • Masters
    • Écoles doctorales
    • Cours internationaux
    • MOOCS
    • Venir en France
  • Galerie

Funded PhD project in Montpellier: optogenetic control of FGF and Eph signaling pathways during ascidian embryogenesis

Page d'accueil Emploi Funded PhD project in Montpellier: optogenetic control of FGF and Eph signaling pathways during ascidian embryogenesis
Emploi

Funded PhD project in Montpellier: optogenetic control of FGF and Eph signaling pathways during ascidian embryogenesis

24 septembre 2019
By Patrick Lemaire
0 Comment
844 Views
Article en anglais


Context: Cell-cell communication plays a central role in the coordination of morphogenesis and fate specification. Most components of the major signalling pathways have been identified, but we lack a quantitative understanding, in time and space, of the dynamics of signal transduction from the membrane to the nucleus. The CRBM Tunicate embryology Research Team uses molecular and 3D + time live imaging approaches to study this process during ascidian embryogenesis ( see a GIF of our work featured in the Xmas 2018 GIFs of The Node).

The PhD project

One of our major projects combines experimental and mathematical modelling approaches to produce a quantitative model of the information flow between membrane and nucleus for one of the major transduction pathways during embryonic development.

We are looking for a PhD student to develop an optogenetic control strategy for the FGF/SOS/Ras/ERK and Eph/RasGAP/Ras signaling pathways. This approach will open the way to a variety of questions including: how long does signal transduction take from the membrane to the nucleus? during which phase (s) of its cell cycle is the cell competent to respond to receptor activation? what is the minimum activation time of the receptor needed to produce a stable nuclear response? what is the function linking the activation level of the receptor and that of ERK? The experimental results will be integrated into a mathematical model, in collaboration with theoreticians.

Activities:

This project is mostly experimental. It will give the selected student a solid expertise in embryology (microinjections, in vitro fertilization…), signal transduction and advanced light-sheet imaging. In addition, the PhD student will frequently interact with the MOSAIC  and ICAR teams of computer scientists, in order to integrate experimental and modelling results.  Participation in public outreach actions (Science festivals, My Thesis in 180 seconds, …) will be encouraged.

Necessary skills

  • Master training in cell biology or development, with a strong interest for embryonic development
  • An interest in mathematical modelling.
  • A first experience in molecular cloning and confocal/light-sheet microscopy of live samples would be appreciated.
  • An experience in RNA or proteins microinjection into oocytes would be a plus but is not required.
  • No Knowledge of French required. Working knowledge in written / spoken English needed.

Application process

This project can be joined directly as a PhD student in fall/winter 2019, or as a Master intern in winter 2019, the PhD only starting in fall 2020. Funding is for 3 years.

Informal enquiries can be made to Patrick Lemaire (patrick.lemaire@crbm.cnrs.fr). Formal applications are through the CNRS employment portal

About the host institute

The host research team is located at a major Cell Biology institute in Southern France, the CRBM (CNRS /U. Montpellier). All seminars and meetings are in English. The institute has a very well-equipped core Imaging facility, hosting a Luxendo MuViSPIM microscope on which lightsheet microscopy experiments will be carried out.

References linked to the project

Leggio, B; Laussu J; Carlier, A; Godin, C; Lemaire, P and Faure, E (2019) MorphoNet: An interactive online morphological browser to explore complex multi-scale data. Nat Commun. 10(1):2812

L. Guignard*, U.-M. Fiuza*, B. Leggio, E. Faure, J. Laussu, L. Hufnagel, G. Malandain, C. Godin#, P. Lemaire# (2017) Contact-dependent cell communications drive morphological invariance during ascidian embryogenesis. bioRxiv 238741

U-M Fiuza, T. Negishi, A. Rouan, H. Yasuo, P. Lemaire  Nodal and Eph signalling relay drives the transition between apical constriction and apico-basal shortening during ascidian endoderm invagination (2018) bioRxiv 418988

Biasuz, K, Leggio, B, Faure, E, and Lemaire, P. (2018) The “computable egg”: Myth or useful concept? Curr. Op. System Biology, 11:91-97

Lemaire P. (2011) Evolutionary crossroads in developmental biology: the tunicates, Development, 138(11):2143-52.

Tassy, O., Daian, F., Hudson, C., Bertrand, V., Lemaire, P. (2006) A quantitative approach to the study of cell shapes and interactions during early chordate embryogenesis. Current Biology 16:345-58

Tags: Doctorat

Previous Story
Joana Estaves De Lima, Boston, 25-30 July 2019
Next Story
3D + time live imaging data analyst and software developer

Postez vos annonces

Tous les adhérents peuvent publier leurs annonces en se connectant à leur compte.

→ Vous n’êtes pas encore adhérents ? Adhérer directement en ligne
Formulaire d’adhésion

→ Adhérents mais pas encore de compte de connexion ? Inscrivez-vous !
Inscription

Toutes les actualités

Archives

  • janvier 2021 (1)
  • décembre 2020 (5)
  • novembre 2020 (4)
  • octobre 2020 (9)
  • septembre 2020 (2)
  • août 2020 (3)
  • juillet 2020 (2)
  • juin 2020 (7)
  • mai 2020 (4)
  • avril 2020 (2)
  • mars 2020 (3)
  • février 2020 (5)
  • janvier 2020 (3)
  • décembre 2019 (3)
  • novembre 2019 (5)
  • octobre 2019 (4)
  • septembre 2019 (2)
  • août 2019 (1)
  • juillet 2019 (4)
  • juin 2019 (4)
  • mai 2019 (2)
  • avril 2019 (1)
  • mars 2019 (2)
  • décembre 2018 (7)
  • novembre 2018 (6)
  • octobre 2018 (4)
  • septembre 2018 (1)
  • août 2018 (1)
  • juillet 2018 (1)
  • juin 2018 (4)

La SFBD sur Twitter

SFBD-BioDevFollow

Avatar
AvatarRichard Behringer@rrbehringer·
19 Jan

Applications are open for the @MBLScience Embryology Course (May 24 -June 30, 2021) for those passionate about developmental biology. @___SDB___ @the_Node https://bit.ly/35U95mC

Reply on Twitter 1351543414123360262Retweet on Twitter 1351543414123360262101Like on Twitter 1351543414123360262199Twitter 1351543414123360262
AvatarYad Ghavi-Helm 🐾@yad_ghavi·
19 Jan

1 week left to apply! We're hiring a technical assistant/lab manager to reinforce our team. Starting asap. #drosophila @ENSdeLyon @IGFLyon https://twitter.com/yad_ghavi/status/1346768085953503232

Yad Ghavi-Helm 🐾@yad_ghavi

We are recruiting!
Looking for an entousiatic technical assitant/lab manager who loves working with flies 😀
en: http://bit.ly/3ngNk6B
fr: http://bit.ly/3ojA1n5
Please RT

Reply on Twitter 1351470115058053120Retweet on Twitter 135147011505805312016Like on Twitter 13514701150580531208Twitter 1351470115058053120
AvatarLe Borgne Lab@LEBORGN54867765·
20 Jan

Find out how PAR3/Bazooka nanoclusters organize Notch signaling units along the apico basal axis during asymmetric division of Drosophila epithelial cells.
Our new findings are now available on bioRXiv https://doi.org/10.1101/2021.01.19.427226

Reply on Twitter 1351797567777079296Retweet on Twitter 135179756777707929611Like on Twitter 135179756777707929639Twitter 1351797567777079296
Load More...

SOCIÉTÉ FRANÇAISE DE BIOLOGIE DU DÉVELOPPEMENT

Contact  Twitter

ILS SPONSORISENT LA SFBD

Copyright ©2019 Société Française de Biologie du Développement. All Rights Reserved. Designed by Bioself Communication. Logo by Melanie Roussat.
SearchPostsLogin
lundi, 4, Jan
Shaping Life 2: exclusively online
mardi, 22, Déc
Sandrine Denaud, conference en ligne, du 17 au 20 mai 2021
jeudi, 17, Déc
Results of the 2021 SFBD Board Election
mardi, 15, Déc
Technicien-ne biologiste
mardi, 8, Déc
Compte rendu de l’Assemblée générale 2020 de la SFBD
samedi, 5, Déc
Ingénieur(e) en bioinformatique – analyse de données trancriptomiques

Welcome back,

Nous utilisons des cookies pour vous garantir la meilleure expérience sur notre site web. Si vous continuez à utiliser ce site, nous supposerons que vous en êtes satisfait.Ok