SFBD
  • Offcanvas Icon
  • LOGIN / REGISTER
  • FAQs
  • French
  • English
SFBD
  • The SFBD
    • About us
    • Join us
    • SFBD members
    • Partner societies
    • Sponsors
    • Contact
  • Actions
    • Thesis Prize
    • Travel grants
    • Support to event organization
    • Career transition grants
    • SFBD online seminars
    • Position statements
  • News
    • News
    • Post your news
    • How to post your news
    • The SFBD letter
  • Jobs
    • Job opportunities
    • Post a job offer
    • How to post a job offer
  • Calendar
  • Resources
    • Online events
    • Outreach
    • Teaching resources
    • Resources for an Informed Audience
    • Model species databases
    • Research groups (GdR)
    • Research Environmental Impact
    • Inclusive Networks
  • Training
    • Masters
    • Doctoral schools
    • International courses
    • MOOCS
    • Coming to France
  • Gallery

Funded PhD project in Jouy en Josas

Homepage Job opportunities Funded PhD project in Jouy en Josas
Job opportunities

Funded PhD project in Jouy en Josas

21 June 2020
By hacloque
0 Comment
901 Views

Context: 

Pluripotent Stem Cells (PSCs) are characterized by their extensive differentiation potential both in vivo and in vitro. They can be obtained by culturing early embryo (ES cells) or by reprogramming of somatic cells (iPS cells). Until recently, PSCs could only be established from rodent or primate embryos and the molecular reasons for the inability to derive PSCs in other species remain poorly understood. One possibility is that these cells carry inappropriate epigenetic marks which limit their pluripotency or that the signaling pathways known to activate the pluripotency network in mice and humans are inactive or insufficient in pigs. Recently, we and other laboratories have performed cell-single transcriptomics (scRNA-seq) studies at different embryonic stages. These new data help to identify the different states of pluripotency of embryonic cells and the signaling pathways that control them. Thanks to a recently funded ANR project (PluS4Pig, 2020-2024) that we are coordinating, we will be able to enrich these existing data sets with new expression, chromatin accessibility (scATAC-seq) and proteomics data. The objective of the project is to use technologies specific to big data to integrate these different biological dimensions in order to predict and then experimentally validate the optimal culture conditions for the expansion of porcine PSCs. The analysis of heterogeneous omics data at the level of the single cell meets the challenges of big data: In fact, we analyze thousands of individuals (cells) for thousands of heterogeneous variables (gene expression, chromatin accessibility, proteome).

The PhD project:

The PhD student will contribute to the prediction and characterization of the different states of pluripotency existing in the pig embryo through in silico analyzes of multi-omic single-cell data. He / she will:

1)  characterize the embryonic molecular micro-environment and the gene networks controlling endogenous pluripotency

2)  predict the signaling molecules necessary and sufficient for the maintenance of porcine pluripotent lines in vitro

3)  disseminate the knowledge acquired on big data analysis to breeding companies in order to anticipate the phenotyping needs on health traits as well as the associated digital tools.

The first two objectives will be coordinated by the academic partner while the third objective will be coordinated by the socio-economic partner IFIP-Institut du Porc.

This project is funded by a collaborative ANR project (PluS4PiGs) which covered all the experimental costs necessary to complete the PhD project. The doctoral student will benefit from an efficient storage and computing infrastructure (http://bioinfo.genotoul.fr/). The PhD student will also benefit from the support of a bioinformatics engineer funded by the ANR project and fully dedicated to single-cell studies. The PhD contract is co-funded by the region Ile de France, the animal genetics division from INRAE and the IFIP-Institut du Porc. The latter will fund trainings dedicated to bioinformatics and single-cell studies to the PhD student as well as one international congress. It will also host the PhD student for dissemination and information activities as well as for writing the thesis manuscript, facilitating interactions with data analysts and statisticians of IFIP. The PhD student will benefit from a solid network of national and international collaborators, specialized in biostatistics and machine learning, bioinformatics and proteomics but also concerning the biological model and the pig sector. The main supervisor of the PhD student (70% supervision rate) has expertise shared between development biology, cell biology and animal genomics and will facilitate the connections between data and biological issues to meet the objectives of the project.

Activities:

This project is mostly focused on data analysis but also includes an experimental part. It will give the selected student a solid expertise for the analysis of single-cell omics data but also in mammalian embryology and cellular biology (culture of pig embryos and pluripotent stem cells and their molecular characterization).

Necessary skills:

A Master degree in bioinformatics/biostatistics or a dual competence in developmental biology/system biology will be favored. Intermediate level in R and Python is required.

Application process:

This project can be joined directly as a PhD student in fall/winter 2020. Funding is for 3 years.

Applications can be made to Hervé Acloque (herve.acloque@inrae.fr).

A more detailed version of the project is available here: https://www.dropbox.com/preview/Public/IdF_AAP_PhD_project_en.pdf

Tags: PhD

Previous Story
Meeting SFBD – From cells to embryo
Next Story
Finalist Thesis Prize SFBD 2020: Dr. Alicia Lardennois

Post your news

 All members can publish their ads by logging into their account. .

→ You are not yet a member? Join directly online
Membership form

→ Members but no login account yet? Sign up now!
Registration

All news

Archives

  • February 2023 (1)
  • January 2023 (3)
  • December 2022 (3)
  • November 2022 (5)
  • September 2022 (1)
  • June 2022 (2)
  • May 2022 (5)
  • April 2022 (5)
  • March 2022 (3)
  • January 2022 (8)
  • November 2021 (6)
  • October 2021 (4)
  • September 2021 (2)
  • August 2021 (4)
  • June 2021 (2)
  • May 2021 (13)
  • April 2021 (23)
  • March 2021 (2)
  • February 2021 (2)
  • January 2021 (1)
  • December 2020 (5)
  • November 2020 (5)
  • October 2020 (9)
  • September 2020 (2)
  • August 2020 (3)
  • July 2020 (2)
  • June 2020 (7)
  • May 2020 (4)
  • April 2020 (2)
  • March 2020 (3)
  • February 2020 (5)
  • January 2020 (3)
  • December 2019 (3)
  • November 2019 (5)
  • October 2019 (4)
  • September 2019 (2)
  • August 2019 (1)
  • July 2019 (4)
  • June 2019 (4)
  • May 2019 (2)
  • April 2019 (1)
  • March 2019 (2)
  • December 2018 (7)
  • November 2018 (6)
  • October 2018 (4)
  • September 2018 (1)
  • August 2018 (1)
  • July 2018 (1)
  • June 2018 (4)

La SFBD sur Twitter

SFBD-BioDev Follow

Official account of the French Society for Developmental Biology

Avatar
Retweet on Twitter SFBD-BioDev Retweeted
Avatar HFSP @hfsp ·
14 Mar

Attention scientists from all over the world🙃HFSP Postdoctoral Fellowships application opens tomorrow! It's time to pitch your creative scientific ideas into a Letter of Intent and kick off your research career with an #HFSPPostdoctoralFellowship🚀What are you waiting for? #hfsp

Reply on Twitter 1635652612031754241 Retweet on Twitter 1635652612031754241 342 Like on Twitter 1635652612031754241 445 Twitter 1635652612031754241
Retweet on Twitter SFBD-BioDev Retweeted
Avatar Andrea Musacchio @andreamusacchio@c.im @andreamusacchi1 ·
10 Mar

Application call for our IMPRS now open!

Reply on Twitter 1634305206396567556 Retweet on Twitter 1634305206396567556 24 Like on Twitter 1634305206396567556 62 Twitter 1634305206396567556
Retweet on Twitter SFBD-BioDev Retweeted
Avatar Florian Jug @florianjug ·
11 Mar

First round of @AI4LifeTeam #OpenCall still open for submissions!

But time is ticking… only 20 days left!
⏳Deadline: March 31, 2023

🚨 Apply now! https://ai4life.eurobioimaging.eu/first-open-call/

We offer to support you with you scientific image data analysis… no strings attached!!!
@EuroBioImaging

Reply on Twitter 1634555359879675904 Retweet on Twitter 1634555359879675904 25 Like on Twitter 1634555359879675904 40 Twitter 1634555359879675904
Load More...

SOCIÉTÉ FRANÇAISE DE BIOLOGIE DU DÉVELOPPEMENT

Contact  Twitter

ILS SPONSORISENT LA SFBD

Copyright ©2019 Société Française de Biologie du Développement. All Rights Reserved. Webmaster Bioself Communication. Logo by Melanie Roussat.
SearchPostsLogin
Wednesday, 1, Feb
Hommage au Professeur Michel Vervoort
Thursday, 19, Jan
Postdoctoral position – Heart Development and Rare Diseases
Monday, 9, Jan
The Marseille Developmental Biology Institute (IBDM) is recruiting group leaders
Friday, 6, Jan
Launch of SFBD Online Seminars!
Wednesday, 28, Dec
Lattice Lightsheet 7 Tour 2023
Wednesday, 28, Dec
EuReCa PhD Program – 8 PhD positions at Institut Curie (COFUND)

Welcome back,