Finalist Thesis Prize SFBD 2020: Dr. Solène Clavreul
→ Prize of 300 €
In 2020, the SFBD has chosen Dr. Solène Clavreul as a co-finalist for the thesis prize for her thesis entitled: “Development of the astroglial network in the murine cerebral cortex”. This work was the subject of two publications in the journal Nature Communication in 2019 (here and here) and a JOVE protocol. Solène Clavreul did her thesis under the supervision of Dr. Jean Livet and Dr. Karine Loulier at the Institut de la Vision in Paris.
The work of the winner :
In the course of her thesis work, Solène Clavreul has endeavoured to answer the long-standing questions of the origin and establishment of the astroglial network in the brain, while also raising the question of their heterogeneity. She performed multicolor clonal analyses to study in particular the composition, positioning and dispersion of these astrocyte clones during brain maturation. This work was made possible by the use of a new 3D imaging approach combining bi-photonic multicolor mosaic microscopy and automatic serial cutting. The results obtained suggest that cortical astrocytes exhibit a high plasticity during development, which has so far been poorly characterized at both the clonal and individual cell scales.